An FTC spokeswoman, Lindsay Kryzak, declined to comment on the petition.
The petition shows how major tech companies are trying to defraud and discredit the efforts of the Biden administration and lawmakers to regulate the industry. They have lobbied against bills that would ban some of their business practices, supported outside advocacy groups defending their position, and hired dozens of lawyers to avoid investigations.
President Biden appointed Ms. Khan chair this month after Congress approved her nomination for a commission seat. He has made no secret of his concerns about the country’s biggest tech companies.
She told lawmakers at her April confirmation hearing that she saw a “wide range of potential risks” surrounding the companies and noted that she intended to try to address those risks while at the agency.
Amazon said that if Ms. Khan were to play a role in Amazon’s antitrust investigations, it would violate federal ethics rules and the company’s right to due process.
The company attached a statement from Thomas D. Morgan, emeritus professor of law at George Washington University, supporting its position. Morgan said Amazon had paid him to give his opinion.